Nickel

Nickel is necessary for the function of active centers of certain enzymes. The influence of nickel on folate metabolism is important. It is needed for hematopoiesis processes. In cell nuclei, nickel can interact with chromatin and stabilize DNA structure. In the blood, it forms complexes with albumin and with a2-microglobulin. It is believed that nickel is important for forming lipoproteins. There are no known phenomena of nickel deficiency, but symptoms of poisoning are known. When larger amounts of nickel enter through the mouth, liver parenchyma necrosis begins. Inhaling nickel dust can cause pneumonia. Lung tumors are more frequently identified in individuals with occupational and domestic exposure to nickel dust. Nickel is present in small amounts in animal-derived food, and in large amounts in plant-derived food. Nickel is abundant in nuts, chocolate, beans, peas, and cereal grains. Nickel has carcinogenic and cumulative properties. It is believed that altered nickel levels may be a cause of myocarditis, lung diseases, skin inflammations, allergic reactions, and nausea.