CINtec Plus test from liquid-based cytology

The CINtec Plus test from liquid-based cytology is a specialized laboratory test that helps assess changes in cervical cells. This test is based on cell analysis, which allows the detection of certain proteins associated with precancerous changes. It is important because it helps in the early detection of cervical cancer risk, thereby contributing to early diagnosis and treatment. Such early intervention can significantly improve treatment outcomes and reduce the risk of complications.

Purpose of the test

The CINtec Plus test is designed to determine whether there are changes in cervical cells that could indicate an increased risk of cancer. The test identifies two specific proteins – p16 and Ki-67, which appear together when pathological processes occur in the cells. P16 is a protein associated with cell cycle regulation, while Ki-67 is a proliferation marker. Together, they can indicate whether the cells have precancerous changes. The CINtec Plus test may be recommended when Pap smear results are unclear or positive, to more accurately determine the risk and the need for further action.

Symptoms and indications

The test is often performed as part of preventive screening, especially for women with abnormal Pap smear results. It may also be recommended in the presence of symptoms such as abnormal bleeding between periods, after menopause, or after sexual intercourse. Additionally, it may be useful for women with an increased risk of cervical cancer due to human papillomavirus (HPV) infection or other factors.

Test procedure

The CINtec Plus test is performed by taking a sample using the liquid-based cytology method. This means that cells are collected with a special brush and then transferred to a liquid medium for further analysis. No special preparation is required before the test, but it is recommended to avoid sexual intercourse or the use of vaginal products 24 hours before the sample is taken. Test results are usually ready within a few days.

Interpretation of results

Test results can indicate whether there are pathological changes in the cells. If p16 and Ki-67 proteins are detected together, it may indicate a higher risk of cancer and the need for further tests, such as a colposcopy. However, elevated markers do not always mean cancer, so it is important to consult with a doctor for further steps. Temporary changes can also occur due to infections or other factors, so regular check-ups are important.

Significance for health

The CINtec Plus test is important for both prevention and early diagnosis of cervical pathologies. It provides valuable information to help prevent more serious complications and monitor cell changes. Early detection of cervical changes allows timely preventive or therapeutic actions, thus reducing the risk of cancer development and improving overall women's health.