Gold

Gold salts are used to treat rheumatoid arthritis. The exact mechanism of action of gold preparations is unknown, but it is believed that treatment gradually blocks the mononuclear phagocyte system. The concentration of gold found in serum during or after treatment does not necessarily reflect the therapeutic or toxic effect of the preparation. However, when the gold concentration increases to more than 20 µmol/l, signs of toxicity may appear. Sometimes, an increase in gold concentration may persist long after treatment. Treatment with drugs saturated with this noble metal can sometimes cause fever, anxiety, and intestinal disturbances. Such preparations should not be used by those suffering from diabetes, tuberculosis, heart, and vascular diseases. Other side effects of using gold salts include kidney damage, itching, rash, the appearance of ulcers on the oral mucosa, tongue, and pharynx. Overall, kidney function should be continuously monitored when using such preparations.