NIPT Pregnancy Loss – pregnancy loss cause investigation (trisomies 21, 18, and 13 + aneuploidies X, Y + large deletions and duplications + analysis of aneuploidies of all remaining chromosome pairs + sex)

Chromosome anomalies and spontaneous miscarriage

Both numerical and structural chromosome anomalies are the most common causes of spontaneous miscarriage. Balanced structural chromosome anomalies can cause recurrent miscarriages, so it is especially important to identify such anomalies during the first miscarriage when planning the next pregnancy. Cytogenetic studies of tissues taken after miscarriage are characterized by a high rate of non-resultative outcomes due to fetal tissue contamination with maternal tissues and cell culture failures. PregnancyLoss

After a miscarriage, placental tissue continues to release free (non-cellular) DNA fragments into the maternal bloodstream for some time. Therefore, after confirming the miscarriage with ultrasound, it is still possible to perform a non-invasive fetal DNA analysis, even if the fetal DNA fraction is very small - this is made possible by a special Veritas algorithm. Checking fetal genetic material for aneuploidies and large deletions and duplications larger than 7Mb provides essential information for genetic counseling when a woman experiences a miscarriage, avoiding the cultivation of miscarriage tissues.

Recommendation for when to perform the test: as soon as possible after the pregnancy loss is observed and definitely before performing a curettage procedure. A blood sample can be taken when the gestational age has reached at least 5 weeks (calculated from the date of the last menstrual period).

Sample: blood.

Time to completion after reaching the laboratory: 2-4 business days.