Ratio of Free-PSA to Total PSA

What is it? 
This test calculates the ratio between the concentration of free prostate-specific antigen (PSA) and total PSA in the blood. PSA is a protein produced by prostate cells, and its increased concentration can indicate both benign and malignant changes. 

When is it recommended? 

• For men with elevated total PSA levels (usually from 4 to 10 ng/ml); 
• Assessing the risk of prostate cancer; 
• Differentiating between benign prostatic hyperplasia (BPH) and a malignant process. 

Patient benefits: 

Allows for a more accurate assessment of risk and reduces the number of unnecessary biopsies. A low free/total PSA ratio often indicates a malignant process, while a higher ratio is characteristic of a benign prostate condition. 

Important to know: 

The accuracy of the test can be influenced by ejaculation, urinary tract infections, or invasive urological procedures – therefore, it is important to follow the doctor's instructions before the test.