CK-NAC | Creatine Kinase

Creatine Kinase (CK-NAC) – it is an enzyme predominantly found in striated skeletal and heart muscles, as well as in brain tissues. This enzyme is involved in energy metabolism processes, being responsible for the rapid regeneration of adenosine triphosphate (ATP) during muscle contraction. The highest creatine kinase activity is observed in newborns, and later, with age, its level gradually decreases.

Increased creatine kinase levels are most often associated with muscle damage. A significant increase in CK is detected in cases of myocardial infarction, Duchenne muscular dystrophy, after muscle injuries, surgical interventions, or intense physical exertion. The enzyme concentration may also increase in certain neuromuscular diseases or when taking certain medications (e.g., statins).

Principle of the study: CK activity is determined by the spectrophotometric method from venous blood. Results are presented in U/l (units per liter). The test is often performed together with CK-MB isoenzyme and troponins to assess heart muscle damage.

Recommendations:

• It is recommended to perform preventively once a year, especially if there is an increased risk of muscle or heart damage.
• Useful in diagnosing myocardial infarction, assessing the degree of muscle damage, or monitoring treatment progress.
• Performed on patients after intense physical exertion, injuries, or when experiencing muscle pain.
• Assigned for monitoring the progress of neuromuscular diseases.
• Physical activity, medications (especially statins), injections, or other muscle injuries can affect test results.
• It is recommended to come for the test fasting for at least 12 hours.