Folic acid in erythrocytes

Folic acid in erythrocytes – this is a test that allows the evaluation of the body's long-term folate reserves. Unlike the serum folic acid concentration, the amount of folic acid in erythrocytes is less dependent on recently consumed food or supplements, thus better reflecting the body's folate supply over the past few months.

Folic acid (vitamin B9) is essential for cell division, DNA and RNA synthesis, protein metabolism, and normal nervous system function. Together with vitamin B12, it participates in the maturation of red blood cells, so its deficiency can cause megaloblastic (macrocytic) anemia. An adequate amount of folic acid is also important during pregnancy, as vitamin B9 is necessary for the normal development of the fetal nervous system.

The test is used to identify and evaluate folic acid deficiency, especially when investigating macrocytic anemia, suspecting folate deficiency, insufficient absorption, or monitoring the effectiveness of prescribed treatment. Test results are always evaluated together with clinical data and other laboratory indicators, such as vitamin B12 concentration, homocysteine levels, and complete blood count.

IMPORTANT: The test is performed only together with CBC | Complete blood count.

Test principle: Folic acid concentration is determined from venous blood erythrocytes using an immunochemical method. Results are presented in nanograms per milliliter (ng/ml) or nanomoles per liter (nmol/l).

Recommendations:

• Recommended when suspecting long-term folic acid deficiency.
• Useful in investigating macrocytic anemia and evaluating its causes.
• Prescribed for patients suspected of folate absorption disorders (e.g., in the case of celiac disease or other gastrointestinal diseases).
• Can be performed to monitor the effectiveness of folic acid treatment.
• It is recommended to come for the test fasting – at least 8 hours, and not to take folic acid supplements 1–2 days before the test unless otherwise instructed by a doctor.