Tryptase determination

What is it? 

Tryptase – is an enzyme produced by mast cells, which are involved in allergic reactions. The concentration of tryptase increases during systemic allergic reactions – anaphylaxis. 

When is it recommended? 

• Suspected anaphylaxis after drugs, food, insect bites; 
• Diagnosis and monitoring of mastocytosis; 
• Allergy assessment when unknown causes trigger a sudden body reaction. 

Benefits: 

Helps confirm a severe allergic reaction even when symptoms have already disappeared. Useful for assessing the risk of recurrence and identifying the exact cause. 

Important to know: 

Blood for the test should be taken within 1–4 hours from the onset of the reaction – this is when the tryptase level is highest. Sometimes repeated tests are ordered to determine the baseline level.