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Chronic pain

Some of the most compelling evidence suggests that the solution to chronic pain could simply be… vitamin D.

According to a comprehensive review of existing studies published on the Pain Treatment Topics website, insufficient vitamin D concentration is associated with numerous diseases, including fibromyalgia, osteoarthritis, rheumatic disorders, and bone, joint, or muscle pain. Vitamin D deficiency can also be linked with pain syndromes unrelated to muscles and bones – neuropathy, migraine headaches, and autoimmune inflammatory diseases, such as inflammatory bowel diseases.

A large portion of these studies focused on chronic muscle and bone pain. The review's author, Dr. Stewart Leavitt, selected 22 clinical studies that examined vitamin D concentrations among patients experiencing such pain. The studies found that, on average, 70% of patients with chronic muscle and bone pain lacked vitamin D. The evidence also indicates that vitamin D supplements can significantly reduce pain. Among 324 women with chronic pain, this vitamin alleviated symptoms in 95% of cases and 100% of those with the most severe vitamin D deficiency (>25 nmol/L). A concentration of 75-100 nmol/L is considered necessary for maintaining bone health.

According to S. Leavitt, vitamin D deficiency may cause muscle and bone pain due to hypocalcemia – low circulating calcium concentration, which triggers a cascade of biochemical reactions that negatively impact bone metabolism and health. One such reaction is the increase in parathyroid hormone (PTH) concentration, which weakens bone mineralization and leads to the formation of porous bone mass. As this mass absorbs fluid, the resulting diffuse pressure causes pain in the tissues covering the bones, which are rich in pain-sensitive fibers.

Regardless of the mechanism, the facts suggest that investigating and correcting vitamin D concentrations in cases of deficiency could be a crucial factor in treating chronic pain.